Multiple Ascending Dose (MAD)
Multiple Ascending Dose (MAD) studies are critical to evaluating the safety, tolerability, pharmacokinetics (PK), and pharmacodynamics (PD) of investigational therapies following repeated administration. CenExel supports sponsors with efficient MAD trial execution, generating the data needed to optimize dosing strategies and advance promising therapies through clinical development.
Studies Conducted
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Trial Participants
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Active Centers
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Overview
Advancing Clinical Development Through MAD Studies
CenExel delivers comprehensive Multiple Ascending Dose study capabilities designed to support early-phase drug development programs. Our experienced clinical teams conduct carefully monitored repeated-dose studies that provide critical insights into drug accumulation, safety profiles, dose proportionality, and therapeutic potential.
We collaborate closely with sponsors to design flexible protocols, ensuring high-quality data collection while maintaining participant safety throughout each dosing cohort.
Conditions Covered
MAD Conditions We Research
Our MAD study capabilities support a wide range of indications, including:
CNS Disorders
Psychiatry
Behavioral Health
Metabolic Diseases
Obesity
Diabetes
Inflammatory Disorders
Rare Diseases
Neurology
Cardiovascular Conditions
Our Approach
Why Sponsors Choose CenExel for MAD Studies
From dose escalation planning to data-driven decision-making, our MAD studies deliver operational excellence, scientific precision, and trusted results at every stage.
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Experienced Early-Phase Teams
Dedicated research professionals with extensive experience conducting complex dose-escalation studies.
02
Advanced PK/PD Capabilities
Comprehensive pharmacokinetic and pharmacodynamic assessments supporting critical development decisions.
03
Real-Time Safety Monitoring
Continuous medical oversight and rapid safety review processes throughout dose escalation.
04
Flexible Study Execution
Scalable infrastructure designed to accommodate diverse protocols and evolving sponsor requirements.
Phase Coverage
Supported Trial Phases
We support Multiple Ascending Dose studies across early clinical development programs, providing reliable execution and actionable data.
Active phases
Phase I
Phase II
Let’s Advance Your Next Study
Looking for an experienced clinical research partner with the expertise, capabilities, and reach to move your study forward? Connect with CenExel to discuss your needs and explore how our network can support your clinical development goals.
Explore Our Network
Discover CenExel’s Centers of Excellence and find the locations, therapeutic expertise, and capabilities that align with your clinical development needs.